The Best Actress Contenders were:

REESE WITHERSPOON (Walk The Line)
The current frontrunner having won majority of the precursors, Golden Globe (Musical/comedy) and SAG awards
FELICITY HUFFMAN (Transamerica)
Also won the Golden Globe (Drama) but the win by Reese at the SAG could indicate where the award will go on the night. Huffman still has a fighting chance having played a very Oscar-bait role (a transsexual)
JUDI DENCH (Mrs Henderson Presents)
The five time nominee and former winner in the supporting actress category (SHAKESPEARE IN LOVE) 1998 is well loved especially by the older members of AMPAS. She could spring a surprise if the Academy decides to go for an older winner.
CHARLIZE THERON (North Country)
Theron was recently in Oscar's winning circle having won for (MONSTER) 2004 and it is hardly likely that she will win again so soon especially for a film not that well received by critics or the general public.
KEIRA KNIGHTLY (Pride and Prejudice)
20 year old Keira got a surprise nomination for a film which won great reviews and a respectable box office. This indicate some support which makes her the dark horse in this category
WINNER: REESE WITHERSPOON (Walk To Line)